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Work closely with DMPK CROs to design, coordinate, monitor and manage external ADME and PK studies. We are looking for a consummate teammate who seeks a scientifically rigorous and collaborative environment in which to grow their career in drug R&D. We are looking for an energetic and passionate Senior/Principal Scientist to join the DMPK team.
Full-timeExpandUpdated 22 days ago - UpvoteDownvoteShare Job
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Leading-edge mindset in relation to current experimental and computational DMPK approaches and techniques. Broad DMPK experience and expertise spanning target assessment to the clinic, with an awareness of regulatory guidance and industry trends.
Full-timeExpandUpdated 26 days ago - UpvoteDownvoteShare Job
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Represent DMPK function on project teams; oversee and integrate all In Vitro and In Vivo ADME, PK, and PK/PD efforts for discovery and preclinical development programs. Job Overview: This job requires partnering with various project teams, setting DMPK strategy, and driving execution of projects in the pharmaceutical industry, utilizing strong expertise in PK/ADME strategies, PK and PK/PD modeling, and excelling in a collaborative and fast-paced team environment.
ExpandApply NowActive JobUpdated 2 days ago - UpvoteDownvoteShare Job
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Perform in vitro ADME/DMPK assays, such as CYP inhibition and metabolic profiling. LC-MS/MS, bioanalytical analysis, HPLC/UPLC, SCIEX QTRAP, Thermo Q, DMPK. Working experience with DMPK lab is a plus.
ExpandApply NowActive JobUpdated 6 days ago - UpvoteDownvoteShare Job
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The Director, Drug Metabolism and Pharmacokinetics (DMPK) for BMS-San Diego, oversees the research activities of the San Diego based team of 9 scientists and will report to the global head of Discovery DMPK within the Pharmaceutical Candidate Optimization (PCO) department.
ExpandApply NowActive JobUpdated 10 days ago - UpvoteDownvoteShare Job
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Collaborate with In Vivo Pharmacology and DMPK on development of translational PKPD models. Develop and integrate timelines and budgets for clinical pharmacology activities with overall company timelines and goals, in close coordination with project management, clinical science, CMC, DMPK, nonclinical development, regulatory affairs and other stakeholders.
ExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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Keep abreast of innovative DMPK/clinical pharmacology technologies, novel pharmacokinetic and pharmacodynamic modeling approaches and regulatory guidelines with the aim of bringing therapies to patients faster or more efficiently.
$220,000 - $240,000 a yearFull-timeExpandUpdated 23 days ago - UpvoteDownvoteShare Job
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Serve as the subject matter expert on cross-functional teams to lead projects, direct GLP bioanalytical validations and sample analysis across all nonclinical, DMPK and clinical pharmacology development.
ExpandApply NowActive JobUpdated 3 days ago - UpvoteDownvoteShare Job
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Be the functional area representative for DMPK on project teams, collaborating closely with medicinal chemistry and biology/pharmacology. Extensive experience optimizing and characterizing the ADME properties of small molecule drug candidates, supported by a strong publication record in DMPK sciences.
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And respond to regulatory inquiries related to DMPK, PK/PD, and clinical pharmacology. Strong knowledge of pharmacokinetics and pharmacodynamics principles, immunogenicity, modelling and simulation, Model-Informed Drug Development, ADME Concepts, and regulatory clinical pharmacology requirements to support clinical development and regulatory submission.
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Oversee and provide strategic direction for Toxicology/Pathology, BioAnalytical/DMPK, Biomarkers, and Clinical Pharmacology teams to ensure robust support for clinical development programs. Oversee and provide strategic direction for Toxicology/Pathology, BioAnalytical/DMPK, Biomarkers, and Clinical Pharmacology teams to ensure robust support for clinical development programs.
$265,000 - $300,000 a yearFull-timeExpandApply NowActive JobUpdated 4 days ago - UpvoteDownvoteShare Job
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Job Description About This Role Biogen is seeking a highly motivated scientist with excellent knowledge and experience in LC-MS/MS bioanalysis to join the Drug Metabolism and Pharmacokinetics (DMPK) department.
Full-timeExpandUpdated 22 days ago - UpvoteDownvoteShare Job
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Works in unison with the development and research teams to evaluate DMPK properties of lead molecules as they relate to modes of administration and molecular design. A deep understanding of PK and ADA assay development principles and techniques (ELISA, MSD, BLI, SPR, MS, %recovery) with precision and accuracy.
Full-timeExpandUpdated 1 month ago - UpvoteDownvoteShare Job
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The Associate Director, Clinical Pharmacology, will be responsible and accountable to lead and execute clinical pharmacology strategies and activities for assigned programs and studies from early through late-stage clinical development and approval, including post marketing activities, and collaborate cross-functional stakeholders including research, DMPK, translational medicine, clinical development, clinical operation, biometrics, regulatory, CMC, and project management.
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Expertise in the area of drug product development, ADME, DMPK, PK, and PBPK modeling is required. They will conduct drug-drug interactions studies including in vitro CYP and UGT inhibition, CYP induction profiling using primary hepatocytes, microsomal metabolic stability, reaction phenotyping using recombinant CYPs and UGTs, solubility, protein binding, blood/plasma partitioning, RNA isolation, mRNA to CDNA conversion and RT-qPCR experiments.
Full-timeExpandApply NowActive JobUpdated Today
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